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Polibiotic (Metronidazole)

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Polibiotic is in a class of drugs called nitroimidazole antimicrobials. This medicine will only help infections caused by bacteria and will not work for the common cold, flu, or other viral infections. It works by stopping the growth of bacteria.

Other names for this medication:
Aldezole, Amevan, Amotein, Anamet, Anerobia, Biozyl, Collazole, Deprocid, Emedal, Etron, Etronil, Farnat, Flagemed, Flagolin, Flagystatine, Giardyl, Ginerella, Ginkan, Grinazole, Gynotran, Kilpro, Lindoplus, Litagyl, Mecozol, Menilet, Metrazol, Metrogel, Metrozole, Negazole, Nidagel, Nidagyl, Nidazole, Nidazyl, Padet, Patryl, Perilox, Rosiced, Tolbin, Torgyl, Trichazole, Trichozole, Tricozyl, Trikozol, Vandazole

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Also known as: Metronidazole


Metronidazole injection is used to treat serious bacterial infections in different areas of the body. It is also used to prevent infections in the bowels before and after surgery for some patients.

Metronidazole belongs to the class of medicines known as antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

This medicine is to be given only by or under the direct supervision of your doctor.


This section provides information on the proper use of a number of products that contain metronidazole. It may not be specific to Polibiotic. Please read with care.

Use this medicine exactly as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered.

This medicine is to be used only in the vagina. Use it at bedtime, unless your doctor tells you otherwise.

Do not get it into your eyes, nose, mouth, or skin. If this medicine does get into your eyes, wash them out right away with large amounts of cool tap water. If your eyes still burn or are painful, check with your doctor.

This medicine comes with a patient information leaflet and patient instructions. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Wash your hands with soap and water before and after using this medicine.

Nuvessa™ is available inside a prefilled applicator. The applicator is open at one end where you will insert the plunger and has a pink cap on the other end where the medicine will come out.

Vandazole® is in a tube. You will use an applicator to put the gel into your vagina. The applicator has a plastic tube called a barrel that is open at one end and has a plunger (another piece of plastic that can move inside the barrel) at the other end.

To use the medicine:

To fill the applicator: For cream or gel dosage forms: Nuvessa™: With the pink cap still on, push the tip of the plunger into the open end of the prefilled applicator. Pull the cap off before you insert the applicator into your vagina. Vandazole®: Break the metal seal at the opening of the tube by using the point on the top of the cap. Screw the applicator onto the tube. Squeeze the medicine into the applicator slowly until it is full. Remove the applicator from the tube. Replace the cap on the tube. For vaginal tablet dosage form: Place the vaginal tablet into the applicator. Wet the vaginal tablet with water for a few seconds. To insert vaginal metronidazole using the applicator: For all dosage forms: Relax while lying on your back with your knees bent (or in any position that you feel comfortable). Hold the full applicator in one hand. Insert it slowly into the vagina. Stop before it becomes uncomfortable. Slowly press the plunger until it stops. Withdraw the applicator. The medicine will be left behind in the vagina. Remove the applicator from your vagina. Use each applicator only once, and then throw it away.

To help clear up your infection completely, it is very important that you keep using this medicine for the full time of treatment, even if your symptoms begin to clear up after a few days. If you stop using this medicine too soon, your symptoms may return. Do not miss any doses. Also, continue using this medicine even if your menstrual period starts during the time of treatment.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For bacterial vaginal infections: For vaginal dosage form (cream): Adults—One applicatorful (500 milligrams [mg]), inserted into the vagina. Use the medicine 1 or 2 times a day for 10 or 20 days. Children—Use and dose must be determined by your doctor. For vaginal dosage form (gel): Nuvessa™: Adults and children 12 years of age and older—One applicatorful (5 grams [g]) inserted into the vagina once (at bedtime). Each applicatorful of Nuvessa™ contains 65 mg of metronidazole. Children younger than 12 years of age—Use and dose must be determined by your doctor. Vandazole®: Adults—One applicatorful (5 grams [g]) inserted into the vagina once a day (at bedtime) for 5 days. Each applicatorful of Vandazole® contains 37.5 mg of metronidazole. Children—Use and dose must be determined by your doctor. For vaginal dosage form (tablets): Adults—One 500 milligram (mg) tablet, inserted high into the vagina. Use the medicine once a day in the evening for 10 or 20 days. Children—Use and dose must be determined by your doctor.


If you overdose Generic Polibiotic and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Polibiotic overdosage: dizziness, seizures, torpor, retching, nausea, lack of balance, problems with coordination, tingling.


Store at room temperature below 25 degrees C (77 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Polibiotic are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

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Recognition of the parallel venous channel is clinically important for the treatment of transverse/sigmoid AVFs. Thus, Arabidopsis CHMP1A and B are ESCRT-related proteins with conserved endosomal functions, and the auxin carriers PIN1, PIN2, and AUX1 are ESCRT cargo proteins in the MVB sorting pathway. Structures were chosen based upon eHiTS ability to accurately identify the majority of estrogenically active compounds given a set of active and decoy molecules. The Indian mothers gave later estimates for crawling than those of the other two groups. Currently, datasets may exceed 4,000 images when angiography is included in routine trauma protocols. The objectives of this study were to (1) characterize cognitive and cerebral correlates of attention and response speed in patients with obstructive sleep apnea (OSA) and (2) assess the association of performance and brain activation with measures of OSA severity. Oral bioavailability enhancement of a hydrophilic drug delivered via folic acid-coupled liposomes in rats. The evolutionary history of biological pathways is of general interest, especially in this post-genomic era, because it may provide clues for understanding how complex systems encoded on genomes have been organized. Gait characteristics of individuals with multiple sclerosis before and after a 6-month aerobic training program. This technique demonstrates the use of a vascularized autograft replacement on a pedicled graft.

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Cell lines propagated from human normal mammary epithelia and from benign or infiltrating components of primary breast tumours express low levels of galectin-3 in the cytoplasm. Functional mapping of receptor specificity domains of glial cell line-derived neurotrophic factor (GDNF) family ligands and production of GFRalpha1 RET-specific agonists. Findings on posteroanterior radiographs alone were compared to posteroanterior and lateral chest radiographs. The results, in vitro, also indicate that pH, incubation time and temperature influence the activity of lactate transporters and the accumulation of lactate into RBC, underscoring the fact that in practice it is important to standardise the measurement conditions of lactate. Innate immune responses involving interferon- beta and the dominant-negative isoform of C/EBP beta were induced at this time. The non-headache control group did not differ significantly from either headache group. Previous theoretical studies indicate that a balance between recurrent excitation and feedback inhibition is important for sustaining the activity.

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